Surrounded by mountain views, the Comfort Inn hotel is located within walking distance of Wythe County Community Hospital.

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Wytheville () is a town in, and the county seat of, Wythe County, in southwestern Virginia, United States. Book the Comfort Inn Wytheville in the Wytheville, Virginia. It is named after George Wythe, a signer of the United States Declaration of Independence, and mentor to Thomas Jefferson. Comfort Inn Wytheville in the Wytheville, Virginia on the detailed map. Wytheville's population was 8,211 at the 2010 census. Comfort Inn Wytheville in the Wytheville, Virginia on the detailed map. Interstate Highways 77 and 81 were constructed to intersect at the town, long a crossroads for travelers. During the American Civil War, Wytheville had a strategic importance. Comfort Inn Wytheville in the Wytheville, Virginia on the detailed map. It was attacked in 1863 (Toland's Raid) and 1865 (Stoneman's 1865 Raid). Comfort Inn Wytheville in the Wytheville, Virginia on the detailed map. The town is the birthplace of Edith Bolling Wilson, second wife of President Woodrow Wilson.. Book the Comfort Inn Wytheville in the Wytheville, Virginia.